AMITRIP P.P.M 25 mg

Indication

Used to treat major depressive disorder. Also used for neuropathic pain, migraine prophylaxis, and nocturnal enuresis. A tricyclic antidepressant that increases serotonin and norepinephrine activity in the brain.

Ingredients

• Amitriptyline HCl

Direction

Adults (depression): Initially 25–75 mg daily in divided doses or as a single dose at bedtime. Dose may be increased gradually under medical supervision. Elderly: Start at lower doses (10–25 mg at bedtime). Do not stop abruptly.

Side effects

• Very common: dry mouth
• sedation
• drowsiness
• blurred vision
• constipation
• urinary retention.
• Common: dizziness
• postural hypotension
• tachycardia
• tremor
• weight gain.
• Uncommon: cardiac arrhythmias
• confusion (especially in elderly).
• Rare: seizures
• agranulocytosis.
• Very rare: liver toxicity.

Precautions

• Contraindicated in hypersensitivity to amitriptyline or tricyclic antidepressants.
• Contraindicated in recent myocardial infarction
• serious arrhythmias
• and mania.
• Do not use with MAO inhibitors — allow 14 days washout.
• Risk of suicidal thinking in children
• adolescents
• and young adults — monitor closely.
• May prolong QT interval — caution with cardiac disease.
• Causes sedation — impairs driving and operating machinery.
• Anticholinergic effects — caution in urinary retention
• glaucoma
• prostatic hypertrophy.
• Lowers seizure threshold — caution in epilepsy.
• Contraindicated in pregnancy and breastfeeding.
• Keep out of reach of children.