Cimetidine Injection 200 mg/2 ml

Indication

Cimetidine injection is an H2-receptor antagonist used for the treatment and prophylaxis of peptic ulcer disease, gastro-oesophageal reflux disease (GORD), Zollinger-Ellison syndrome, and prevention of stress ulcers in critically ill patients. It may also be used to reduce gastric acid secretion prior to surgery.

Ingredients

• Cimetidine

Direction

Adults: 200 mg by slow intravenous or intramuscular injection every 4–6 hours. The IV dose should be diluted and administered over at least 2 minutes. Total daily dose should not normally exceed 2,400 mg. Dose adjustment required in renal impairment.

Side effects

• Diarrhoea
• nausea
• dizziness
• and headache.
• Reversible confusional states
• particularly in elderly patients.
• Gynaecomastia and impotence with long
• term use.
• Elevated serum creatinine (without true renal impairment).
• Rare: bradycardia
• hypotension (with rapid IV injection)
• hepatotoxicity
• agranulocytosis.

Precautions

• Use with caution in patients with renal or hepatic impairment — dose reduction may be required.
• Cimetidine inhibits cytochrome P450 enzymes and has multiple drug interactions (warfarin
• phenytoin
• theophylline
• lidocaine
• etc.).
• IV bolus administration has been associated with rare cases of bradycardia and hypotension — inject slowly.
• Avoid in patients with known hypersensitivity to cimetidine or other H2 antagonists.
• Use with caution in immunocompromised patients.
• Keep out of reach of children.