Diabetmin 500 mg

Indication

Diabetmin (metformin 500 mg) is a biguanide antidiabetic used as first-line pharmacotherapy for type 2 diabetes mellitus, particularly in overweight patients, when diet and exercise alone are insufficient to achieve glycaemic control. Also used off-label in polycystic ovary syndrome (PCOS).

Ingredients

• Metformin

Direction

Adults: Initially 500 mg 2–3 times daily with or after meals; increase gradually based on blood glucose response. Usual maintenance dose: 1,500–2,000 mg/day in 2–3 divided doses. Maximum: 3,000 mg/day. Take with meals to reduce gastrointestinal side effects.

Side effects

• Nausea
• vomiting
• diarrhoea
• and abdominal discomfort (most common
• especially at initiation).
• Metallic taste.
• Vitamin B12 deficiency with long
• term use.
• Rare but serious: lactic acidosis (particularly in predisposed patients).

Precautions

• Contraindicated in renal impairment (eGFR < 30 mL/min/1.73 m²) — risk of lactic acidosis.
• Suspend before iodinated contrast media procedures and restart 48 hours after if renal function is stable.
• Contraindicated in hepatic failure
• excessive alcohol intake
• and conditions predisposing to hypoxia.
• Temporarily discontinue before major surgery.
• Monitor renal function at least annually.
• Keep out of reach of children.