Diane-35 Not available

Indication

Used in women for the treatment of androgen-dependent conditions such as severe acne (with or without seborrhea), hirsutism, and alopecia. Also acts as an oral contraceptive during treatment.

Ingredients

• Cyproterone acetate
• Ethinylestradiol

Direction

Take 1 tablet daily for 21 consecutive days, starting on day 1 of the menstrual cycle. Follow with a 7-day tablet-free interval during which a withdrawal bleed usually occurs. Take at the same time each day, with a little liquid if necessary.

Side effects

• Common: headache
• nausea
• breast tenderness
• mood changes
• breakthrough bleeding.
• Common: decreased libido.
• Serious: venous thromboembolism (deep vein thrombosis
• pulmonary embolism).
• Rare: liver tumors
• arterial thrombosis (stroke
• myocardial infarction).

Precautions

• Contraindicated in patients with history of venous thromboembolism
• arterial thromboembolism
• or known thrombophilic conditions.
• Contraindicated in active liver disease or history of liver tumors.
• Contraindicated in hormone
• sensitive malignancies (breast cancer
• endometrial cancer).
• Contraindicated in undiagnosed vaginal bleeding.
• Contraindicated in pregnancy.
• Increases risk of venous thromboembolism compared to other combined oral contraceptives.
• Smoking significantly increases cardiovascular risk
• strongly advise not to smoke.
• Regular blood pressure monitoring recommended.
• Keep out of reach of children.