Metformin Denk 500 500mg

Indication

Metformin hydrochloride is a biguanide antidiabetic agent used as first-line therapy for type 2 diabetes mellitus, both as monotherapy and in combination with other antidiabetics or insulin, to improve glycemic control.

Ingredients

• Metformin HCl

Direction

Adults: Initial dose 500 mg once or twice daily with meals. Dose may be gradually increased to 1500–2000 mg/day in divided doses. Maximum 3000 mg/day. Take orally with or immediately after meals to reduce gastrointestinal side effects.

Side effects

• Nausea
• vomiting
• diarrhea
• abdominal pain (common at initiation
• usually transient).
• Metallic taste.
• Vitamin B12 deficiency with long
• term use.
• Lactic acidosis (rare but serious).
• Hypoglycemia (rare when used as monotherapy).

Precautions

• Contraindicated in patients with renal impairment (eGFR <30 mL/min/1.73 m²).
• Temporarily discontinue before contrast media use and after certain surgical procedures.
• Risk of lactic acidosis (rare but serious) — especially with renal or hepatic impairment
• excessive alcohol use.
• Use with caution in patients with hepatic impairment.
• Monitor renal function periodically.
• Vitamin B12 absorption may decrease with long
• term use.
• Keep out of reach of children.