Cocilone 1 mg per uncoated tablet

Indication

Used for the treatment and prophylaxis of acute gout attacks and other crystal-related arthropathies.

Ingredients

• Colchicine

Direction

1 mg immediately, followed by 0.5 mg (half tablet) every 2 hours until pain is relieved or vomiting and diarrhea intervene. Maximum dosage of 6 mg daily. Refer to package insert for indication, contraindications, administration and side effects.

Side effects

• May cause nausea
• vomiting
• abdominal pain
• or diarrhea
• which are early signs of overdose and should prompt dose reduction.
• Stop use and seek urgent medical care if severe diarrhea
• muscle weakness
• unusual bleeding
• severe allergic reaction
• or other serious symptoms occur.

Precautions

• For use under prescription only.
• Do not exceed the maximum dose of 6 mg per acute attack and observe a minimum interval before repeat courses.
• Use with caution in elderly patients and those with renal
• hepatic
• gastrointestinal
• or cardiac disease.
• Avoid in patients with severe renal or hepatic impairment unless under specialist supervision.
• Avoid concomitant use with strong CYP3A4 or P
• glycoprotein inhibitors (e.g. clarithromycin
• ketoconazole) without medical advice.
• Consult a doctor before use during pregnancy or while breastfeeding.
• Keep out of reach of children.