Micardis Plus 40/12.5 40 mg / 12.5 mg

Indication

Treatment of essential hypertension in adults whose blood pressure is not adequately controlled on telmisartan alone. Fixed-dose combination of an angiotensin II receptor antagonist (Telmisartan) and a thiazide diuretic (Hydrochlorothiazide).

Ingredients

• Telmisartan 40 mg
• Hydrochlorothiazide 12.5 mg

Direction

Adults: take one tablet daily, swallowed whole with liquid, with or without food. Dose should be adjusted by a doctor based on blood pressure response.

Side effects

• Common: dizziness
• hypotension
• hypokalaemia
• hyperuricaemia
• hyperglycaemia
• headache.
• Less common: rash
• photosensitivity
• gastrointestinal upset
• fatigue
• syncope.
• Rare but serious: angioedema
• acute renal failure
• severe electrolyte disturbances
• hepatic dysfunction
• pancreatitis.
• Stop use and seek medical attention immediately for swelling of the face
• lips or tongue
• severe rash
• fainting
• or sudden decrease in urine output.

Precautions

• Prescription
• only — use only under medical supervision.
• Do not use in pregnancy (especially in the 2nd and 3rd trimesters) or breastfeeding.
• Do not use in patients with anuria
• severe hepatic impairment (Child
• Pugh C)
• cholestasis or biliary obstruction
• severe renal impairment
• refractory hypokalaemia
• hypercalcaemia
• or known hypersensitivity to telmisartan
• hydrochlorothiazide
• other sulphonamide
• derived drugs
• or any of the excipients.
• Monitor renal function
• serum electrolytes (especially potassium) and uric acid periodically.
• Use with caution in patients with renal artery stenosis
• congestive heart failure
• primary aldosteronism
• diabetes mellitus
• or systemic lupus erythematosus.
• Dehydration
• salt depletion or concurrent use of other antihypertensives may cause symptomatic hypotension — drink adequate fluids.