Esopep 40 mg (lyophilized powder + 10 ml sterile WFI)

Indication

Intravenous proton pump inhibitor for patients who cannot take oral therapy: gastro-oesophageal reflux disease with oesophagitis and/or severe reflux symptoms, healing and prevention of NSAID-associated gastric ulcers, and prevention of rebleeding after endoscopic treatment of bleeding gastric or duodenal ulcers.

Ingredients

• Esomeprazole (as sodium) 40 mg per vial
• Diluent: Sterile Water for Injection (USP) 10 ml

Direction

For hospital use, administered by a healthcare professional; dosage as directed by the physician. IV injection: reconstitute the vial with 10 ml of sterile water for injection and inject slowly over at least 3 minutes. IV infusion: reconstitute, then dilute with 100 ml of 0.9% sodium chloride or 5% glucose solution and infuse over 10-30 minutes. Do not refrigerate the reconstituted solution; use within 12 hours, preferably freshly prepared.

Side effects

• Headache
• abdominal pain
• diarrhoea
• nausea
• flatulence
• constipation
• Injection
• site reactions
• Dizziness
• rash or itching
• Rarely allergic reactions
• low sodium or magnesium levels
• liver enzyme changes
• Consult a doctor or pharmacist before use and stop if irritation or allergy occurs.

Precautions

• Prescription medicine
• to be sold on prescription of a registered medical practitioner only
• Do not use if allergic to esomeprazole or other proton pump inhibitors
• do not combine with nelfinavir
• Exclude gastric malignancy before treatment
• Use with caution in severe liver impairment
• pregnancy and breast
• feeding
• Long
• term PPI use may increase the risk of fractures
• low magnesium and certain intestinal infections
• Consult a doctor or pharmacist before use and stop if irritation or allergy occurs.