Sitagliptin/Metformin Sitagliptin 50mg + Metformin 500mg

Indication

This combination is used to improve glycaemic control in adults with type 2 diabetes mellitus as an adjunct to diet and exercise. Sitagliptin is a DPP-4 inhibitor and metformin is a biguanide that reduce blood glucose through complementary mechanisms.

Ingredients

• Sitagliptin 50 mg
• Metformin hydrochloride 500 mg

Direction

Adults: Take one tablet twice daily with meals to reduce gastrointestinal side effects. Dose may be adjusted by the physician based on blood glucose monitoring and renal function. Do not use in type 1 diabetes or diabetic ketoacidosis.

Side effects

• Nausea
• vomiting
• diarrhoea
• abdominal discomfort (common with metformin)
• Nasopharyngitis
• upper respiratory tract infection (sitagliptin)
• Headache
• Hypoglycaemia (especially in combination with other antidiabetics)
• Pancreatitis (rare
• but serious)
• Metallic taste

Precautions

• Contraindicated in patients with eGFR < 30 mL/min/1.73 m² (renal impairment).
• Do not use if allergic to sitagliptin
• metformin
• or any excipient.
• Discontinue before iodinated contrast procedures and restart only after renal function is reassessed.
• Risk of lactic acidosis with metformin — avoid in hepatic impairment
• excessive alcohol intake
• or conditions causing tissue hypoxia.
• Sitagliptin has been associated with acute pancreatitis — discontinue if pancreatitis is suspected.
• May cause hypoglycaemia when used with insulin or sulfonylureas.
• Not recommended during pregnancy or breastfeeding.