ERYTHRO-MS 250 250mg

Indication

ERYTHRO-MS 250 contains erythromycin, a macrolide antibiotic used for the treatment of bacterial infections including respiratory tract infections (pneumonia, bronchitis, whooping cough), skin and soft tissue infections, sexually transmitted infections (chlamydia, syphilis in penicillin-allergic patients), and as an alternative for patients allergic to penicillin.

Ingredients

• Erythromycin 250 mg

Direction

Adults: 250–500 mg four times daily (every 6 hours), or 500 mg–1 g twice daily, for 7–14 days. Take with food to reduce GI side effects. Children: 30–50 mg/kg/day in divided doses. Complete the full course.

Side effects

• Nausea and vomiting (most common — dose
• related).
• Abdominal cramps.
• Diarrhoea.
• Cholestatic hepatitis (with prolonged use).
• QT prolongation and arrhythmias (rare).
• Hearing loss (rare
• with high doses).
• Skin rash.

Precautions

• Use with caution in patients with hepatic impairment — erythromycin is metabolised in the liver.
• May cause QT interval prolongation — caution with other QT
• prolonging medicines.
• Erythromycin is a potent inhibitor of CYP3A4 — significant drug interactions with many medicines (statins
• warfarin
• carbamazepine
• etc.).
• May cause cholestatic jaundice with prolonged use.
• Not recommended for use with ergot alkaloids.
• Keep out of reach of children.