Omeprazole GPO 20mg 20mg

Indication

Omeprazole GPO 20 mg is a proton pump inhibitor (PPI) used for the treatment of gastric and duodenal ulcers, gastro-oesophageal reflux disease (GORD), erosive oesophagitis, Zollinger-Ellison syndrome, and as part of Helicobacter pylori eradication regimens.

Ingredients

• Omeprazole 20 mg

Direction

Adults: 20–40 mg once daily before a meal (morning preferred), for 4–8 weeks. H. pylori eradication: 20 mg twice daily for 7–14 days (in combination with antibiotics). Maintenance of GORD: 10–20 mg once daily. Swallow capsules/tablets whole — do not crush or chew.

Side effects

• Headache.
• Diarrhoea.
• Nausea.
• Abdominal pain.
• Flatulence.
• Constipation.
• Hypomagnesaemia with long
• term use.
• C. difficile diarrhoea (rare).
• Bone fractures with prolonged use (rare).

Precautions

• Long
• term use may reduce magnesium absorption — monitor serum magnesium in patients on prolonged therapy.
• Prolonged use may increase risk of Clostridium difficile diarrhoea.
• Long
• term use associated with increased risk of bone fractures and vitamin B12 deficiency.
• May mask symptoms of gastric malignancy — rule out cancer before initiating therapy.
• Use with caution in patients with severe hepatic impairment.
• Interactions with clopidogrel
• methotrexate
• warfarin — consult a pharmacist.
• Keep out of reach of children.