Glucophage 500 mg

Indication

Treatment of type 2 diabetes mellitus.

Ingredients

• Metformin hydrochloride

Direction

Oral use. As directed by physician.

Side effects

• Nausea
• vomiting
• diarrhoea (very common
• especially at initiation).
• Abdominal pain or discomfort.
• Loss of appetite.
• Metallic taste in mouth.
• Lactic acidosis (rare but potentially fatal).
• Vitamin B12 deficiency with prolonged use.

Precautions

• Contraindicated in patients with renal impairment (eGFR < 30 mL/min/1.73 m²).
• Contraindicated in patients with hepatic impairment.
• Contraindicated in patients with diabetic ketoacidosis.
• Withhold before and after use of iodinated contrast media (at least 48 hours).
• Risk of lactic acidosis (rare but serious)
• discontinue if signs of hypoxia
• dehydration
• or acute illness occur.
• May cause vitamin B12 deficiency with long
• term use
• periodic monitoring recommended.
• Use with caution in elderly patients.
• Alcohol increases the risk of lactic acidosis.
• Dose adjustment required in moderate renal impairment.