Barole 20 20mg

Indication

A proton pump inhibitor (PPI) used to treat gastro-oesophageal reflux disease (GERD), peptic and duodenal ulcers, erosive oesophagitis, and Zollinger-Ellison syndrome. Also used in combination with antibiotics for Helicobacter pylori eradication.

Ingredients

• Rabeprazole Sodium

Direction

Adults: 20 mg once daily before meals (usually in the morning) for 4–8 weeks. For H. pylori eradication: 20 mg twice daily in combination with antibiotics as per triple therapy regimen, for 7–14 days. Swallow whole — do not crush or chew.

Side effects

• Common: headache
• diarrhoea
• nausea
• abdominal pain
• flatulence
• constipation.
• Common: dry mouth
• rash.
• Uncommon: hepatitis
• elevated liver enzymes.
• Rare: hypomagnesaemia (with long
• term use).
• Rare: interstitial nephritis.
• Very rare: severe skin reactions (Stevens
• Johnson syndrome).

Precautions

• Do not use if allergic to rabeprazole
• other PPIs
• or benzimidazole derivatives.
• Long
• term use may increase risk of hypomagnesaemia — monitor magnesium in prolonged therapy.
• Long
• term PPI use may be associated with reduced vitamin B12 absorption.
• Increased risk of Clostridium difficile
• associated diarrhoea with prolonged use.
• Possible increased risk of bone fracture with long
• term high
• dose use.
• Use with caution in severe hepatic impairment.
• Use with caution in patients taking clopidogrel — some PPIs may reduce antiplatelet effect.
• Keep out of reach of children.