Advantec 16 mg / 12.5 mg

Indication

Fixed-dose combination used to treat hypertension (high blood pressure) when monotherapy with either candesartan or hydrochlorothiazide alone is insufficient. Candesartan is an ARB that blocks angiotensin II; hydrochlorothiazide is a thiazide diuretic that promotes sodium and water excretion.

Ingredients

• Candesartan Cilexetil
• Hydrochlorothiazide

Direction

Adults: One tablet (Candesartan 16 mg / Hydrochlorothiazide 12.5 mg) once daily. Dose may be adjusted under medical supervision. Take with or without food at the same time each day.

Side effects

• Common: dizziness
• nasopharyngitis
• hypokalaemia.
• Uncommon: hypotension
• renal impairment.
• Rare: angioedema — seek immediate medical attention.
• Hydrochlorothiazide: photosensitivity
• gout exacerbation
• elevated blood glucose.
• Very rare: neutropenia
• agranulocytosis.

Precautions

• Contraindicated in pregnancy — can cause severe fetal injury or death.
• Contraindicated in severe hepatic impairment
• anuria
• refractory hypokalaemia
• and hypercalcaemia.
• Contraindicated in hypersensitivity to candesartan
• hydrochlorothiazide
• or sulfonamides.
• Do not use with aliskiren in patients with diabetes or renal impairment.
• Monitor electrolytes (potassium
• sodium)
• renal function
• and blood pressure.
• Risk of hypokalaemia (hydrochlorothiazide) and hyperkalaemia (candesartan) — monitor serum potassium.
• Hydrochlorothiazide may worsen diabetes control and raise uric acid (gout risk).
• Photosensitivity reactions reported with hydrochlorothiazide — use sun protection.
• Keep out of reach of children.