Augmentin 228 mg/5 mL

Indication

Augmentin 228 mg/5 ml suspension (Amoxicillin 200 mg + Clavulanic acid 28.5 mg per 5 ml) is a paediatric broad-spectrum antibiotic used in children for the treatment of bacterial infections including otitis media, sinusitis, lower respiratory tract infections, urinary tract infections, and skin/soft tissue infections caused by beta-lactamase-producing organisms.

Ingredients

• Amoxicillin
• Clavulanic Acid

Direction

Dose is weight-based: typically 25–45 mg/kg/day of amoxicillin component, divided every 12 hours (e.g. 0.3–0.5 ml/kg/dose twice daily for 228 mg/5 ml). Reconstitute with water to the marked line and shake well. Refrigerate after reconstitution; discard after 7 days. Take with food.

Side effects

• Diarrhoea
• nausea
• vomiting — very common.
• Abdominal discomfort
• rash — common.
• Candidal overgrowth — common.
• Elevated liver enzymes — uncommon.
• Anaphylaxis — rare but serious.

Precautions

• Do not use if allergic to penicillins
• cephalosporins
• or beta
• lactam antibiotics.
• Serious hypersensitivity reactions (anaphylaxis) possible.
• Use with caution in renal impairment.
• May cause Clostridioides difficile
• associated diarrhoea.
• Monitor liver function in prolonged use.
• May reduce efficacy of oral contraceptives.
• Keep out of reach of children.