Colpotrophine 10 mg

Indication

Colpotrophine (Promestriene 10 mg) is a vaginal oestrogen used for the local treatment of vaginal atrophy and symptoms of urogenital atrophy in peri- and post-menopausal women, including vaginal dryness, itching, burning, and dyspareunia (painful intercourse). Promestriene is a topical oestrogen with very low systemic absorption.

Ingredients

• promestriene

Direction

Insert one pessary or apply the cream intravaginally each evening for 20 days, then reduce to 2–3 times weekly for maintenance, or as directed by a physician. Use the applicator provided. Wash hands before and after use.

Side effects

• Local irritation
• burning or itching at application site — uncommon.
• Vaginal discharge — uncommon.
• Systemic oestrogenic effects — very rare due to minimal absorption.
• Allergic reactions — rare.

Precautions

• Do not use if allergic to promestriene or oestrogens.
• Do not use in patients with unexplained vaginal bleeding
• oestrogen
• dependent tumours (breast cancer
• endometrial cancer)
• active or past thromboembolic disease
• or severe liver disease.
• Although systemic absorption is minimal
• periodic gynaecological review is recommended.
• Report any unusual vaginal bleeding to a doctor immediately.
• Consult a doctor before use in patients with history of endometriosis or uterine fibroids.
• Keep out of reach of children.