Cotrim P.P.M 200 mg / 40 mg per 5 mL

Indication

Cotrim P.P.M oral suspension is a sulphonamide-antibiotic combination used for the treatment of urinary tract infections, respiratory tract infections (including Pneumocystis jirovecii pneumonia), otitis media, and certain gastrointestinal infections caused by susceptible organisms.

Ingredients

• sulfamethoxazole
• trimethoprim

Direction

Adults: 20 mL (800 mg sulfamethoxazole / 160 mg trimethoprim) every 12 hours for 5–14 days depending on infection. Children 6–12 years: 10 mL every 12 hours. Children 6 months–5 years: 5 mL every 12 hours. Adjust dose in renal impairment.

Side effects

• Nausea
• vomiting
• anorexia
• and diarrhoea.
• Skin rashes and photosensitivity.
• Haematological effects: thrombocytopenia
• leucopenia (rare).
• Stevens
• Johnson syndrome or toxic epidermal necrolysis (rare but serious).
• Elevated serum creatinine.

Precautions

• Contraindicated in patients with severe sulphonamide hypersensitivity or known folate deficiency.
• Not recommended in neonates under 6 weeks due to risk of kernicterus.
• May cause severe skin reactions (Stevens
• Johnson syndrome
• toxic epidermal necrolysis) — discontinue immediately.
• Monitor renal and hepatic function in prolonged use.
• Maintain adequate fluid intake to prevent crystalluria.
• Avoid in severe renal impairment (CrCl < 15 mL/min) without dose adjustment.
• Keep out of reach of children.