Febo-G 40mg

Indication

Used for the treatment of chronic hyperuricemia in conditions where urate deposition has already occurred (including a history of or current gout tophus and/or gouty arthritis).

Ingredients

• Febuxostat

Direction

Adults: 40 mg once daily. If serum uric acid remains above 6 mg/dL after 2–4 weeks, the dose may be increased to 80 mg once daily. Take with or without food.

Side effects

• Common: gout flares (especially early in treatment)
• liver enzyme elevations.
• Common: nausea
• rash.
• Uncommon: dizziness
• headache.
• Rare: serious cardiovascular events
• serious skin reactions (Stevens
• Johnson syndrome).

Precautions

• Contraindicated in patients currently receiving azathioprine
• mercaptopurine
• or theophylline.
• Gout flares may occur when initiating treatment
• prophylaxis with NSAIDs or colchicine is recommended.
• Cardiovascular risk: cardiovascular mortality was higher with febuxostat than allopurinol in one trial
• use with caution in patients with established cardiovascular disease.
• Monitor liver function periodically.
• Use with caution in severe renal or hepatic impairment.
• Keep out of reach of children.