Medicime 200 200mg/2ml

Indication

Medicime 200 (Cimetidine 200 mg/2 mL injection) is an H2-receptor antagonist used to treat peptic ulcer disease, Zollinger-Ellison syndrome, gastroesophageal reflux, and to prevent stress ulcers. Given by injection for acute conditions or when oral administration is not possible.

Ingredients

• Cimetidine

Direction

Adults: Administered by slow IV injection over at least 5 minutes (200 mg diluted in 20 mL of compatible solution), or by IM injection, every 4–6 hours. Typical dose: 200–400 mg IV/IM every 4–6 hours. Maximum: 2.4 g/day. Dosage adjusted for renal impairment.

Side effects

• Headache
• dizziness
• Diarrhea
• nausea
• Gynecomastia and sexual dysfunction with prolonged use
• Confusion
• particularly in elderly or renally impaired patients
• Elevated serum creatinine
• Drug interactions (CYP450 inhibition)

Precautions

• Inject IV slowly to avoid cardiac arrhythmias with rapid injection.
• Use with caution in patients with renal or hepatic impairment (dose reduction required).
• Cimetidine is a potent inhibitor of CYP450 enzymes — significant drug interactions with warfarin
• phenytoin
• theophylline
• lidocaine
• and many other drugs.
• May increase serum creatinine (without affecting true glomerular filtration).
• Use with caution in elderly patients (increased risk of confusion).
• Not recommended during pregnancy unless clearly necessary.
• Keep out of reach of children.