Zoliget 30mg+4mg 30mg+4mg

Indication

Management of type 2 diabetes mellitus in adults when metformin is inappropriate or insufficient. Pioglitazone improves insulin sensitivity; glimepiride stimulates pancreatic insulin secretion.

Ingredients

• Pioglitazone
• Glimepiride

Direction

Adults: One tablet (30 mg pioglitazone + 4 mg glimepiride) once daily with or immediately before the first main meal of the day. Dose should be individualized based on glycaemic response and tolerability.

Side effects

• Hypoglycaemia (low blood sugar)
• Weight gain
• Fluid retention and oedema
• Anaemia
• Dizziness
• Nausea
• Increased risk of bone fractures
• Upper respiratory tract infection

Precautions

• Contraindicated in type 1 diabetes mellitus or diabetic ketoacidosis.
• Contraindicated in patients with heart failure (NYHA Class I–IV) — pioglitazone may cause fluid retention.
• Contraindicated in patients with active or history of bladder cancer.
• Risk of hypoglycaemia
• especially with missed meals or increased physical activity.
• Monitor liver function periodically.
• Pioglitazone may cause or worsen oedema.
• Associated with increased risk of bone fracture in women.
• Not recommended in severe renal or hepatic impairment.
• Keep out of reach of children.