Jentin Met 50mg/1000mg

Indication

Management of type 2 diabetes mellitus in adults as an adjunct to diet and exercise when both sitagliptin and metformin are appropriate. Sitagliptin is a DPP-4 inhibitor that increases incretin levels; metformin reduces hepatic glucose production and improves insulin sensitivity.

Ingredients

• Sitagliptin
• Metformin HCl

Direction

Adults: The recommended dose is one tablet of Sitagliptin 50 mg + Metformin 1000 mg twice daily with meals. The dose should be individualized. Take with food to reduce gastrointestinal side effects from metformin.

Side effects

• Nausea
• vomiting
• diarrhoea (metformin — usually transient)
• Abdominal pain
• Upper respiratory tract infection
• Nasopharyngitis
• Headache
• Hypoglycaemia when combined with insulin or sulfonylurea
• Pancreatitis (rare)
• Lactic acidosis (rare but serious — related to metformin)

Precautions

• Contraindicated in patients with eGFR < 30 mL/min/1.73 m² (severe renal impairment).
• Contraindicated in patients with metabolic acidosis
• including diabetic ketoacidosis.
• Withhold before and 48 hours after iodinated contrast media administration.
• Risk of lactic acidosis with metformin — caution in conditions predisposing to hypoxia.
• May cause pancreatitis — discontinue if symptoms develop.
• Sitagliptin may cause joint pain (arthralgia) — discontinue if severe.
• Use with caution in elderly patients due to potential renal impairment.
• Keep out of reach of children.